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Immunostaining for PCNA also showed that treatment with insulin and IGF-1 increased PCNA positive cell numbers in the cultured metatarsal bone sections (Figure 1e and 1f)

It should be pointed out that the expression of Nrf2 target genes differs between neurons and glial cells (especially astrocytes), with glial cells predominating

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Ipamorelins impact is less hypothalamic and more pituitary-local, so together they alter central feedback loops without completely supplanting hypothalamic control