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In addition, many natural substances (such as root and bark extracts) have not been thoroughly studied and may in fact contain hormonally active chemicals that are actually detrimental to male fertility

Wilmes A, Limonciel A, Aschauer L, Moenks K, Bielow C, Leonard M O, Hamon J, Carpi D, Ruzek S, Handler A and Schmal O 2013 Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

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Studies on lumbar ESIs have revealed that they can provide reliable pain relief for up to 6 months in many cases