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This may be relevant for people with malabsorption disorders such as Crohn's disease or coeliac disease, though it's important to note that for pernicious anaemia, intramuscular hydroxocobalamin injections remain the first-line treatment in the UK, as recommended by NICE and the British Society for Haematology

Vitamin B12 injections are a safe and effective way to treat B12 deficiency, and we commonly recommend them for patients who have trouble absorbing this essential vitamin from food or oral supplements

a portion of the NR/NMN is lost in the gut and liver

Choosing between B12 shots and IV therapy depends on several factors