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[PUBMED Abstract] Goldstein AM, Xiao Y, Sampson J, et al.: Rare germline variants in known melanoma susceptibility genes in familial melanoma

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RAGE activation leads to mitochondrial oxidative stress and the ROS generated within mitochondria activate Bax-Bak proteins, triggering mitochondrial cytochrome C release and subsequent activation of the caspase-9/3 cascade 140