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Shaking introduces mechanical stress that can break the chemical bonds that hold a peptide together

By reducing oxidative stress, the therapy may help protect cells from damage linked to environmental toxins, chronic illness, or intensive physical activity

Deciphering the reversible glutaredoxin-dependent redox reactions of roGFP2 therefore not only closes a gap in our knowledge of glutaredoxin catalysis but also facilitates the intrepretation of roGFP2 responses from redox measurements and mechanistic analyses in vivo

Importantly, JHU08 and ICB combinatorial therapy was effective against tumors that were otherwise ICB resistant