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Mechanistically, the combination therapy suppressed NF-B-mediated inflammatory signaling by downregulating the expression of hepatic pro-inflammatory genes, such as TNF- , IL-6, and MCP-1

5 Adrenal hormonal imbalance-associated oxidative stress Adrenal hormonal imbalance-related oxidative stress is caused by dysregulation in the finely tuned endocrine system, specifically the adrenal glands (49)

These proteins bind to NF-B proteins and mask their DNA binding domains

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