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In addition, strategies for further improving microbial synthesis of heme are proposed, such as enhancing the expression of heme synthetic module, finding the endogenous heme exporter or dynamically regulating the expression of the heterologous heme exporter, and optimizing the fermentation processes such as iron supply
Indeed, more studies have proven the efficacy of 4-methyl-esculetin in IBD models

Nephrol Ther 17(3):160167 Brar R et al (2014) Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats

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