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In a previous study, we have reported that KEAP1 mutant tumors respond to CB-839 treatment, while growth of wild type tumors is unaffected in vivo (Romero et al., 2017)
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Klopstock T, Priglinger C, Yilmaz A, Kornblum C, Distelmaier F, Prokisch H
396 Moreover, CISD2 dissociates Beclin-1 from the PI3K-III complex and therefore leads to the inhibition of autophagy and resistance against sorafenib-induced ferroptosis
