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This is likely due to increased production of O 2 by the mitochondria, leading to oxidation and inactivation of the ACO-2 substrate, and hence further accumulation of citrate to promote increased mtDNA synthesis

Antiarthritic effect The animal-related experiment procedures in this work were conducted according to the guidelines approved by the Animal Ethics Committee of Shanghai Tenth Peoples Hospital, Tongji University School of Medicine (SHDSYY-2020-Z0026/1)

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