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Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, et al

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes
The spermicidal and antitrichomonas activities of SSRI antidepressants

However, highly active tumor cells can create profound changes in nutrient, oxygen concentration, and acidity in TME that affect the metabolism program in immune cells and eventually achieve immune evasion
