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Targeted inhibition of gut microbial trimethylamine N-oxide production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic Kidney disease

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A decrease in these bacterial populations can reduce the metabolic process turning primary bile acids into secondary bile acids (e.g., deoxycholic acid and lithocholic acid) through processes like depolymerization and 7-dehydroxylation

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