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doi: 10.1111/dth.14240

Desensitization by -arrestin binding and downregulation Binding of -arrestin to the phosphorylated receptor with its concentration [ A ] defines the binding constant

Klenerman, P., Hinks, T

They identified the iron storage protein, ferritin light chain 1 (FTL1), as a pro-ageing neuronal factor: its overexpression in the hippocampus of young mice accelerated cognitive decline, whereas knockdown in aged mice preserved synaptic integrity and prevented cognitive deterioration
