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Trazodone/Low-Dose Antidepressants (Off-Label) Mechanism: Serotonergic/antagonist profiles that increase sleep continuity for some

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Feature Medication Type FDA-approved Active ingredient Average weight loss Price Wegovy Pen Once weekly Yes Semaglutide 15% in a year* Starts at $199 Wegovy Pill Once daily Yes Semaglutide 14% in a year* Starts at $149 Two ways to take Wegovy Same active ingredient

Optic neuropathy in vitamin B 12 deficiency