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In mice with deficient peroxisomes in astrocytes and neurons, no axonal degeneration has been detected [43], however, a selective peroxisomal deficiency in oligodendrocytes leads to early axonal loss and neuroinflammation with no demyelination [44] suggesting that oligodendrocyte-axonal and myelin-axonal integrity is important in AMN

5 days/week (~12 mg/day): ~13 vials 3/week (2 mg): ~12 vials 16 weeks: ~3 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 8 weeks (5 days/week): ~40 syringes 16 weeks (5 days/week): ~80 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per 50 mg vial for reconstitution

doi: 10.1038/sj.bjc.6690176

These results introduce a language model of metabolite-like chemical space, which we named DeepMet