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[DOI] [PubMed] [Google Scholar] Carmel R, Gott PS, Waters CH, Cairo K, Green R, Bondareff W, DeGiorgio CM, Cummings JL, Jacobsen DW, Buckwalter G

The most common genetic alterations in GBM involve the inactivation of tumor suppressor genes, such as p53, PTEN, and retinoblastoma (RB1), leading to uncontrolled cell proliferation, escape from apoptosis, and genomic instability [14, 16]

2.2 GSH in redox signaling GSH regulates redox-dependent cell signaling

The glutaminase inhibitor CB-839, while exhibiting preliminary activity in KEAP1/NRF2-mutant NSCLC (extending median PFS by 2
