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In turn, the receptor phosphorylation promotes STATs phosphorylation and dissociation from the GHR as well as the dimerization and translocation to the nucleus, where it activates specific transcription elements on DNA and regulates the transcription of different genes, including IGF-1 ( Figure 1 )

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In one embodiment, the ratio of CD3 :CD28 antibody bound to the beads ranges from 100: 1 to 1 : 100 and all integer values there between

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