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Muscular Force Is Reduced in Neurofibromatosis Type 1

The activation of AHR caused the upregulation of GLP-1 and IL-22 at proteins and mRNA levels, decreased systemic LPS, improved gut barrier function, activated the hepatic STAT3/IL-22R/peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) and pancreatic GLP-1R/p-CREB signaling pathways, and improved lipid metabolism and insulin resistance

They also participate in the metabolic conversion of glutamate to glutamine and store glycogen, which can be utilized during high cognitive activity and hypoglycemia state

[link] Chattopadhyay, A., Yang, X., Mukherjee, P., Sulaiman, D., Fogelman, H.R., Grijalva, V., Dubinett, S., Wasler, T.C., Paul, M.K., Salehi-Rad, R., Mack, J.J., Iruela-Arispe, M.L., Navab, M., Fogelman, A.M., and Reddy, S.T., "Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer", 8 (1): 9032-9043 (2018)