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Riboflavin deficiency may be associated with an increased risk of anemia during pregnancy, and RCTs conducted in pregnant populations have demonstrated that the inclusion of riboflavin with other micronutrient supplements (namely iron and folic acid) leads to greater improvements in hematological parameters, such as hemoglobin concentration, RBC count, and anemia prevalence (reviewed in 62)

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Human fertility papers have reported use of 48 mg daily , making 4 mg in SPERMACTIVE a clean match to the lower end of published male-fertility dosing