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Mol Med 13: 396-406
Importantly, the intraosseous delivery of AAV-delivered Chac2 shRNA in db/db mice with periodontitis markedly reduced neutrophil-aggravated systemic inflammatory comorbidity symptoms and improved glycemic control, underscoring the functional relevance of this pathway in diabetic comorbidity
In addition, ADCP induced by daratumumab binding to monocytes and macrophages enhances cell killing mechanisms, as mAb-coated cancer cells are rapidly phagocytized by macrophages [69]
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