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109,110 Strategies that target GHR signaling The most successful strategy to date for directly inhibiting GHR function has undoubtedly been peptide receptor antagonists, exemplified by the clinically used GHR antagonist pegvisomant (see below)
As NAD+ decreases, mitochondrial oxidative phosphorylation suffers, which produces less ATP and more reactive oxygen species (ROS)
GHK-Cu modulates gene expression in fibroblasts to increase collagen production
