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Description
It is activated by spontaneous hydrolysis of C3 to C3b and C3a, followed by binding of C3b to an infected cell or pathogen

And SCFAs are important factors regulating cytokine secretion and antibody synthesis ( Inhibitory Mechanism of TPs on SARS-CoV-2 Recent studies have demonstrated that TPs, particularly EGCG, inhibit coronavirus enzymes as well as coronavirus replication in vitro ( via activating Nrf2, can suppress ACE2 (a cellular receptor for SARS-CoV-2) and TMPRSS2 (the cell entry that mediates the virus) ( Data from docking simulations and in vitro assays suggest that EGCG is capable of inhibiting the SARS-Cov-2 major protease activity and thus can be used to interfere with SARS-Cov-2 infection ( Evidence suggests that patients infected with RNA viruses are in a chronic oxidative stress state, which is induced by the activation of phagocytes to produce and release ROS, and leads to the depletion of antioxidant defense systems ( Overall, TPs have antiviral solid and antioxidation properties that may help reduce the risk of developing severe COVID-19 symptoms

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The ambiguous role of GPx1 in cancer may be explained by the suppression of oxidative stress-induced inflammation and mutagenesis (DNA damage), but also by the blockade of apoptotic cell death, which in turn may result in enhanced survival of cancer cells (Brigelius-Floh and Kipp 2009)
