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Oxidative stress is a condition where reactive oxygen species overwhelm antioxidant defenses

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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The Keap1 cysteine residue-mutant and electrophile-modified Keap1, both of which have lost the ability to ubiquitinate Nrf2, often retain the capacity to bind with Nrf2
