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Description
By blocking NNMT, it prevents the methylation reaction that depletes SAM and nicotinamide, thereby preserving both cofactors and restoring the metabolic machinery that NNMT overexpression had suppressed

it is probably the most widely used in vivo assay for studying angiogenesis

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Cuprizone (cpz) damages oligodendrocyte homeostasis by chelation of copper and induction of oligodendrocyte apoptosis with subsequent demyelination (Cammer and Zhang, 1993, Skripuletz et al., 2011)
