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By blocking NNMT, it prevents the methylation reaction that depletes SAM and nicotinamide, thereby preserving both cofactors and restoring the metabolic machinery that NNMT overexpression had suppressed

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it is probably the most widely used in vivo assay for studying angiogenesis

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Cuprizone (cpz) damages oligodendrocyte homeostasis by chelation of copper and induction of oligodendrocyte apoptosis with subsequent demyelination (Cammer and Zhang, 1993, Skripuletz et al., 2011)

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