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Future research must address challenges in identifying reliable biomarkers, understanding subphenotype-specific mechanisms, and integrating ferroptosis inhibitors into existing therapeutic frameworks

Extensive cohort and methodological analyses underscore significant inter- and intra-individual variability in gut microbial markers over time, suggesting that a single snapshot profile may be inadequate for predicting probiotic responsiveness (575)

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They underscore the need for additional study of PRL in diverse clinical breast cancers, changes with disease progression and therapeutic pressure, and influences of the metastatic sites