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In the gastrointestinal tract, vitamin B12 protein complexes are degraded by pepsin and the acidic environment of the stomach [17,18,40]
With branded products commanding having experienced intermittent supply constraints, compounding pharmacies stepped in to fill the gapoperating under Section 503A of the Federal Food, Drug, and Cosmetic Act, which exempts qualifying compounders from certain FDA requirements, including CGMP compliance, labeling requirements, and premarket approval
Blaser MJ, Parsonnet J
