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Therefore, unlike with reduced folates where intestinal absorption is followed by direct incorporation into the liver, some of the UMFA in the portal blood likely bypasses the liver to subsequently bind to folate receptors on peripheral tissues such as the kidney (58)
It is the most common cause of severe vitamin B12 deficiency in the UK and mainly affects those over 70 years of age
This is particularly important during life transitions (such as pregnancy, entering menopause, or major illness) when additional support may be needed to maintain thyroid stability and mood
