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[1] Toxicity is extremely rare, though adverse reactions including hypersensitivity can occur, particularly with injectable forms

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Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits

Contamination happens easily and ruins entire vials