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Interestingly, immune cells also exhibit complex metabolic patterns similar to those seen in tumors There is a significant difference in energy consumption between immune cells in resting and activated states ( + T cells and impeding tumor growth ( Under normal physiological conditions, hepatic stellate cells (HSC) are usually in a quiescent state, primarily functioning to store retinyl esters or metabolites containing vitamin A ( The liver, as an immune-exempt organ, contains a large number of macrophages, including resident Kupffer cells and recruited macrophages ( Under the influence of tumor-derived factors, myeloid cells are hijacked to become MDSCs, which not only suppress the anti-tumor function of T cells, but also accelerate tumor progression through promoting angiogenesis, cell invasion, and formation of metastatic pre-metastatic niches

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Acknowledgements We thank PhD student Tatyana Ivanova (Institute of Biochemistry and Genetics of Ufa Scientific Centre RAS) for assistance with some experiments