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prophylaxis for migraine headaches (not effective for acute therapy) Contraindications: hepatic disease or significant dysfunction pregnancy (valproate was upgraded from Category D to Category X in 2013)(FDA Drug Safefy & Availability) Side Effects: Several epidemiologic studies have indicated a higher incidence of & an increased incidence of cardiovascular, orofacial & digital abnormalities in the offspring of mothers who took valproate during pregnancy

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