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3 All doses effectively reduced HbA1c and fasting blood glucose, with the 80 mg and 120 mg doses showing the greatest weight loss compared to placebo

Pioglitazone, a diabetes medication, may benefit selected patients with biopsy-proven NASH, but is also specialist-led and off-label , with potential risks including weight gain, fluid retention, heart failure, and increased fracture risk

Both had a protective effect on cataract progression

Thus, these studies highlight the importance of sustained stress paradigms for modeling the progressive nature of neurodegenerative diseases
