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It has been established that tyrosine kinase inhibitors (TKIs) have various cutaneous adverse effects, with skin and hair depigmentation being relatively common but hair repigmentation occurring less frequently 187 - 189

Alleviation of Cadmium ChlorideInduced Acute Genotoxicity, mitochondrial DNA disruption, and ROS Generation by Chocolate Coadministration in mice liver and kidney tissues [J]
Previous studies failed to detect 7-hydroxymitragynine in fresh kratom leaves, leading to the hypothesis that its presence in marketed kratom products may be due to chemical oxidation (autoxidation) of mitragynine during the postharvest phase (Ponglux et al., 1994

Leave it on for 15-20 minutes before rinsing off with lukewarm water
