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Epitalon restores the spindle integrity and rescues mislocalized cortical granules It is well known that aging of oocytes causes numerous morphological and cellular changes, including alterations and displacement of spindle structure, misalignment of chromosomes, displacement of first polar body and CGs, and premature exocytosis of CGs

FIGURE 2 The accumulation of methylmalonic acid (MMA) and Hcy because of these disruptions leads to oxidative damage and impaired methylation

Site-specific CGRP innervation coincides with bone formation during fracture healing and modeling: a study in rat angulated tibia