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Longer continuous use may lead to receptor downregulation and diminished returns
Kinetic and structural studies have suggested that the inhibitors could be divided into two categories: (a) those able to bind to the -KG/isocitrate site and then act as binding competitors

Anti PVL-antibody titres in the human serum before and after the run through the column were analysed by ELISA

doi: 10.1038/nri2506 47 VegliaFSansevieroEGabrilovichDI
