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However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia

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If your ALT or AST levels change significantly, your prescribing provider should evaluate the context, considering whether you have baseline liver disease, how rapidly you are losing weight (rapid fat loss can temporarily increase liver enzyme release), and whether any concomitant medications could be contributing

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