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MT was discovered in 1957 by Vallee and Margoshe from purification of a Cd-binding protein from horse (equine) renal cortex

Acta 184 (7), 19231931 (2017)

Isoalantolactone inhibits IKKbeta kinase activity to interrupt the NF-kappaB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma

Collectively, these data indicate that the significantly reduced Aldh2 activity of Aldh2 KI mice results in elevated toxic aldehydes levels and, especially 4-HNE and increased 4-HNE adduction to proteins involved in mitochondrial reduced FAO and mitochondrial respiration of BAT, leading to markedly decreased FAO rate and mitochondrial respiration and subsequent reduced adaptive thermogenesis and energy expenditure