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Second generation corticosteroids Beclomethasone diproprionate and slow release budesonide are second generation corticosteroids with a high affinity for the intracellular glucocorticoid receptor in the GI tract, exerting local and selective, potent anti-inflammatory effects at the site of inflammation[33]

However, very high doses unlikely providing proportionally greater benefits due to receptor saturation

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22 Homeostasis In principle, these concepts 14 - 25 consider homeostasis, (cytoprotection/adaptive cytoprotection, organoprotection) as the organs protection from injury as well as organs recovery after injury, as the most important result