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For each plate, the concentration of product was normalized by assigning a score of 0 (0%) to the negative control (average of maximal concentration of product measured in the presence of enzyme without any inhibitor) and a score of 1 (100%) was assigned to the positive control (average minimal concentration of product measured in the presence of enzyme with the reference inhibitor, i.e., EA)

DNA Repair and Genomic Stability Pathways DNA repair pathways receive substantial enhancement, with 47 DNA repair genes stimulated

The initial reactions of cholesterol synthesis, to the formation of isopentenyl pyrophosphate, are commonly referred to as the mevalonate pathway

Mitochondrial dysfunction, a key feature of AD, further exacerbates ROS production, impairs ATP generation, disrupts calcium homeostasis, and ultimately induces neuronal apoptosis (Zhang et al., 2024)