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The American College of Chest Physicians (ACCP)/Canadian Thoracic Society (CTS) 65 recommend oral intake of NAC in moderate-to-severe COPD patients to prevent acute exacerbation

This process, triggered by inflammasome activation, is marked by cell swelling, membrane rupture, and the release of intracellular contents, leading to a pronounced inflammatory response (30)

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Bakht Ramin Shah., Bin Li., Ling Wang., Shillin Liu., Yan Li and Jin Weiping
