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Another prospective cohort study indicated an overall lower cancer incidence and mortality with higher dietary intake of menaquinone (98)

Epigenetic and Cellular Reprogramming: By blocking NNMT-mediated methylation of nicotinamide, preserves NAD salvage pathway activity, increases SIRT-1 signaling, reduces histone deacetylation, and promotes metabolic reprogramming toward oxidative phosphorylation and glycolysis balance, supporting tissue repair and energy homeostasis 1-4

Youll know youre at stage 3 or 4 when your total-B12 levels are low (though sometimes they may not be), and when your MMA and homocysteine levels rise