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Nrf2 inducers, such as sulforaphane from cruciferous vegetables, and tert-butylhydroquinone (tBHQ) (Kraft et al

Safety profiles are favorable (mild somnolence, rare discontinuation), and cost is low, both of which are attractive for adjunctive use while larger, phenotype-stratified RCTs mature

Researchers can also evaluate where to source emerging compounds like retatrutide and monitor retatrutide availability as backup options within their weight management research programs