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Ischemia reperfusion injury is encountered across a wide range of clinical settings where blood flow is temporarily interrupted and then restored

High basal NRF2 activity in acute myeloid leukemia (AML) has been attributed to constitutive NF-B-mediated upregulation of the NFE2L2 gene and is believed to be one cause of resistance to chemotherapy in AML cells (138)

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Currently there is no effective treatment for patients with SLC6A8 deficiency