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PROEX 215/17 and 093.7/21), and conformed to EU Directive 2010/63EU and Recommendation 2007/526/EC regarding the protection of animals used for experimental and other scientific purposes, enforced in Spanish law under Real Decreto 1201/2005

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5.5 Cyclodextrin inclusion complexes Cyclodextrins (CDs) enhance silymarin solubility and dissolution, with HP--CD increasing solubility 20-fold and oral bioavailability 2.02.1-fold in rats ( 5.6 Lipid nanoparticles Lipid-based nanoparticles such as solid lipid nanoparticles (SLNs) and NLCs have the potential to protect against enzymatic degradation by lipases and release in a controlled manner and via a lymphatic path of delivery