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Biochemical parameters profile simulation The biochemical parameters profile simulation was performed using the best overall spectral filters combination in PLS to illustrate the prediction quality of the models in one of the bioreactor assays, by applying the chemometric method that demonstrated relatively reduced predictive performance, and the most established one for this type of application in pharmaceutical bioprocesses

This approach may broaden the therapeutic applicability of existing CAR T cells and contribute to the development of next-generation therapies

VGF is a neurosecretory protein that primarily functions via its downstream proteoforms, with putative roles in metabolic regulation, A clearance and synaptogenesis 48,49,50