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The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment

Sci Rep 2016;6:18528

L-carnitine can help address deficiencies and may improve the overall functioning of the kidneys

These results argue against the possibility that SMN deficiency leads to GABA deficiency by altering the balance of cortical cell populations, suggesting the direct involvement of neuronal cell-specific mechanisms