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The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment

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Sci Rep 2016;6:18528

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L-carnitine can help address deficiencies and may improve the overall functioning of the kidneys

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These results argue against the possibility that SMN deficiency leads to GABA deficiency by altering the balance of cortical cell populations, suggesting the direct involvement of neuronal cell-specific mechanisms

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