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Conclusion Evidence from animal models has clearly demonstrated that there is increased gut permeability, assessed by direct measurement, in experimental models of hypertension

150.Liu M, Fang X, Yang Y, Wang C

Since dermal periostin in PN shows no significant correlation with other pruritogenic mediators in the dermis (including IL-31, IL-31R, and OSMR), it might be an independent contributor to pruritus in PN (64)