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Most protocols suggest administration first thing in the morning on an empty stomach and again before bed

3.4.2 Probiotic impact on adaptive immune response Dendritic cells are of very significant importance in the immune reaction of infected tissue since they can capture different antigens and travel to the lymph nodes, where they expose antigens to nave CD4+ T cells

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[DOI] [PubMed] [Google Scholar] 112.Chang O.K., Ha G.E., Han G.S., Seol K.H., Kim H.W., Jeong S.G., Oh M.H., Park B.Y., Ham J.S