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It was found that probiotics VSL#3 treatment could upregulate the expression of microRNA-146a (miR-146a) and block the BTG2/Bax (B-cell translocation gene 2/Bcl-2-associated X protein) axis in POCD mice, thus inhibiting neuronal apoptosis and reducing oxidative stress (Mao et al., 2021)

Semaglutide is a GLP-1 receptor agonist with approximately 94% sequence homology to native human GLP-1

Overall, these data reveal a marked antihypertensive benefit of CagriSema and represent an important advance for patients with obesity-related hypertension, which often remains refractory and is a leading driver of cardiovascular disease worldwide