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Description
Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy
Absence of Grx5 in yeast (yGrx5) was not lethal [113] but led to constitutive oxidative damage, cellular iron accumulation, and inactivation of ironsulphur containing enzymes but not heme-containing enzymes [113]
Furthermore, a diet rich in GSH-precursors might delay cancer onset in healthy BRCA2 -mutation carriers by limiting FA toxicity
DMOG treatment also reduced GSSG level, that was found elevated in AGS cellular models and AGS patients cells suggesting a relieved oxidative stress (Fig
