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1988, 4.Downey D., Larrabee W

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Most events were reported as mild-to-moderate and concentrated during dose escalation

We set out to characterize the process of spine maturation in the larval zebrafish tectum with the goals of 1) identifying an appropriate developmental window to study spine development, 2) monitoring protrusion dynamics during the filopodia-to-spine transition, 3) defining the relationship between PSD95 accumulation and spine development, and 4) determining if PyrN spine maturation is disrupted in fmr1 mutant larvae