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While generally considered safe, use during pregnancy and breastfeeding should be discussed with a doctor

FDA doesnt support the use of benzyl alcohol and formulations containing it in pediatric patients

Table 18: Efficacy Results in Study JMCH Based upon prospectively defined criteria (modified Southwest Oncology Group methodology) the objective tumor response rate for pemetrexed plus cisplatin was greater than the objective tumor response rate for cisplatin alone

Older patients are also at a higher risk of developing a deficiency in B12
